Antimicrobial and Cytotoxic Evaluation of New Quinazoline Derivatives
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چکیده
منابع مشابه
Synthesis and antimicrobial activity of some bis-quinazoline derivatives.
The hitherto unknown bis[quinazolin-4-one-2-yl]-m-phenylene (2d), and its 3-N-substituted derivatives were prepared from the corresponding bis[3,1-benzoxazin-4-one-2-yl]-m-phenylene (1) as precursor. The quinazolinone derivative 2d was converted into bis[quinazolin-4-thioxo-2-yl]-m-phenylene (3) via different routes, bis[4-chloroquinazolin-2-yl]-m-phenylene (8) and bis[4-hydrazinoquinazolin-2-y...
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Novel series of spiro[(2H,3H)-quinazoline-2,1'-cyclohexane] derivatives (I-XVI) were synthesized and biologically evaluated as cytotoxic agents against human breast carcinoma cell lines (MCF-7) using doxorubicin as a reference drug. Most of the tested compounds displayed promising cytotoxic activity, especially derivatives V, VIb and XIb. The most active compounds were docked into the PARP-1 en...
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A highly efficient and versatile synthetic approach to the synthesis of annelated quinazoline derivatives viz. 3,4,9,10a-tetraazaphenanthrenes 5 – 7, thiazolidinylquinazoline 9, 2,4,9,10a-tetraazaphenanthrene 11, quinazolino[4,3-b]quinazolin-8-one 12 and imidazoquinazolines 14a,b, 15. Also, a variety of pyrazolylquinazolines 19 – 21, pyrimidinylquinazolines 22a,b were obtained via a sequence of...
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A series of arylamidines 3a-j was designed, synthesized and investigated for antimicrobial activity. Structures of the compounds were confirmed by IR, 1H-NMR and 13C-NMR and a 2D spectroscopic study was performed. A preliminary screening of the antimicrobial tests clearly showed that three out of ten arylamidines, viz, 3f, 3g and 3i, were effective against all the gram-negative bacteria: Klebsi...
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Resistance to bacterial and fungal strains towards existing antimicrobial agents has become an increasing incietment for research and development of new molecules to guard them. Quinazoline ring system could be clubbed into many ring systems which lead to potent and highly active compounds. In this work, series of eighteen compounds were docked into the ecKAS III binding site (1HNJ, PDB ID) by ...
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ژورنال
عنوان ژورنال: Natural Product Communications
سال: 2016
ISSN: 1934-578X,1555-9475
DOI: 10.1177/1934578x1601101105